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Description
Rabbit IgG polyclonal Picoband? antibody for Superoxide dismutase [Cu-Zn](SOD1) detection. Tested with WB in Human;Mouse;Rat. No cross reactivity with other proteins. Superoxide dismutases (SOD) are a class of enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide. As such, they are an important antioxidant defense in nearly all cells exposed to oxygen. One of the exceedingly rare exceptions is Lactobacillus plantarum and related lactobacilli, which use a different mechanism.Cu,Zn-SOD was found widely distributed in the cell cytosol and in the cell nucleus, consistent with it being a soluble cytosolic protein. Mitochondria and secretory compartments did not label for this protein. In human cells, peroxisomes showed a labeling density slightly less than that of cytoplasm.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of Human SOD1 (116-146aa RTLVVHEKADDLGKGGNEESTKTGNAGSRLA), different from the related mouse and rat sequences by two amino acids.