A selective inhibitor of cytohesins, blocking human, mouse, and Drosophila cytohesins with IC50 values of 2.4 to 5.6 μM; prevents cytohesin-dependent insulin signaling in HepG2 cells; produces hepatic insulin resistance in mice
Size
25 mg
Concentration
n/a
Applications
n/a
Other Names
signals transductions inhibitors inhibits inhibitions intracellular signaling diabetes cancers cytohesins GEFs guanine nucleotide exchange factors insulin resistance hepatic drosophila steppke receptor-mediated receptors mediated cells proliferation selective adenosine diphosphate ribosylation Arfs GTPases pathways Secin H3 H 3 three blocking blocks humans mouse Sec7 Sec 7 seven domains small Arf-GEFs binds larger liver carcinoma HepG2 cells Hep G2 G 2 two prevents cytohesin-dependent dependents mice produces hepatic development regulations