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Description
Function: Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis.Subunit: Interacts with SYTL4, VAPA and SYBU. Found in a complex with VAMP8 andSNAP23. Part of the SNARE core complex containingSNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Binds STXBP6. Found in a ternary complex with STX1A andSNAP25.Subcellular location: Membrane, Single-pass type IV membrane protein.Tissue specificity: Expressed predominantly in cerebral cortex, hippocampus, cerebellum, adrenal medulla and retina with weak expression detected in non-neuronal tissues. Also known as: Syntaxin-1A, Synaptotagmin-associated 35 kDa protein, P35A, Neuron-specific antigen HPC-1, Sap, Syntaxin 1A.
Immunogen
A synthetic peptide from mouse Syntaxin-1A conjugated to blue carrier protein was used as the antigen.