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Description
Basigin (EMMPRIN, CD147) is a type I integral membrane receptor protein belonging to the immunoglobulin superfamily . Basigin is a glycosylated protein with four known isoforms, of which isoform 2 is the most abundantly expressed . Multiple functions have been ascribed to Basigin, foremost among these is stimulating the secretion of extracellular matrix metalloproteinases by adjacent fibroblasts, a function which has been implicated in promoting tumor progression . Research studies have shown that Basigin is overexpressed by many tumor cells, and its expression level may correlate with tumor malignancy . A recent study identified the BASIGIN gene as a regulatory target of Slug, suggesting a role for Basigin in the process of epithelial-mesenchymal transition . Basigin has also been identified as a marker for a subset of highly suppressive regulatory T cells , and as an obligate receptor for the malarial parasite Plasmodium falciparum on human erythrocytes . Synonyms: 5F7, CD147, EMMPRIN, M6, OK, TCSF,