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Description
Rabbit anti-Human IRS2 (aa 600-650) polyclonal antibody for WB,IP. This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.
Immunogen
The immunogen recognized by this antibody maps to a region between residue 600 and 650 of human insulin receptor substrate 2 using the numbering given in entry NP_003740.2 (GeneID 8660).