A peptide hormone; binds to heteromeric complexes of human CTR2 with RAMP1 or 3 (IC50s = 7.86 and 6.35 nM, respectively); binds to mouse α-TSH cells (IC50 = 10.5 nM) and rat nucleus accumbens membrane preparations (Ki = 0.024 nM); inhibits insulin-induced, but not basal, glycogen synthesis in hepatocytes isolated from fasted rats (100 nM); inhibits insulin-induced glycogen synthesis ex vivo in isolated soleus muscle from fasted rats; delays gastric emptying in rats (ED50 = 69 pmol) and decreases food intake in fasted mice (ED50 = 110 μg/kg),