Recombinant Mouse DNA- (apurinic or apyrimidinic site) lyase (Apex1)
Description
2-317aa, Full Length of Mature Protein. MW: 35,490 Da. Purity >85% (SDS-PAGE). Apurinicapyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5 to the AP site. This gene encodes the m