Recombinant Saccharomyces cerevisiae TATA-box-binding protein (SPT15)
Description
Purity > 90% as determined by SDS-PAGE. MW: 28.9kDa. Full Length of Mature Protein: 2-240aa. N-terminal 6xHis-tagged. Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). General transcription factor that functions at the core of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA elent) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.