1888-2201aa; Partial. MW: 39.6kD. Purity >90% as determined by SDS-PAGE. Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
The complete cDNA sequence of human hexabrachion (Tenascin). A multidomain protein containing unique epidermal growth factor repeats.Nies D.E., Hemesath T.J., Kim J.H., Gulcher J.R., Stefansson K.J. Biol. Chem. 266:2818-2823(1991) Human tenascinprimary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies.Siri A., Carnemolla B., Saginati M., Leprini A., Casari G., Baralle F., Zardi L.Nucleic Acids Res. 19:525-531(1991) Structure of the hum