Recombinant Human NGFR (TNFRSF16)-Fc Chimera (carrier-free)
Description
Human nerve growth factor receptor (NGFR) is a type 1 transmembrane glycophosphoprotein of approximately of 75 kD and it belongs to the low affinity neurotrophin receptor and tumor necrosis factor receptor superfamily. It is characterized by an extracellular domain containing four 40 amino acid repeats with six cysteine residues at conserved positions, and disruption of these cysteine-rich repeats leads to loss of ligand binding. NGFR induces different effects depending on its interaction with other proteins. Its interaction with sortilin induces apoptotic responses, while its interaction with LINGO-1 and Nogo-A participates in the myelin-dependent inhibition of axonal growth. Interacting with the neurotrophin tyrosine kinase receptors (Trks) promotes survival, axonal growth, and differentiation of neural cells. The presence of NGFR/CD271 defines a subset of multipotential mesenchymal stromal cells derived from bone marrow. It has been identified as a marker of tumor initiating cells in human melanoma, esophageal carcinoma, hypopharyngeal carcinoma, and head and neck squamous cell carcinomas. Also, NGFR has been associated with glioblastoma cell migration and invasion.