Purity: > 95% by SDS - PAGE Format: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol. HINT1, also known as Histidine triad nucleotide-binding protein 1, is a member of superfamily named for a near C-terminal HXHXHXX motif (H:Histidine, X:a hydrophobic amino acid) positioned at the alpha-phosphate of nucleotide substrates. This protein hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2. Although it was originally thought to be a protein kinase C inhibitor and act as a haplod-insufficient tumor suppressor including spontaneous tumor formation in Hint+/- and Hint-/- , its actual physiologic function is not known. Recombinant human HINT1 protein was expressed in E.coli and purified by using conventional chromatography.
Size
0.5mg, 100ug, 20ug
Concentration
n/a
Applications
SDS-PAGE
Other Names
Histidine triad nucleotide-binding protein 1, Histidine triad nucleotide-binding protein 1, HINT, PKCI-1, PRKCNH1, Histidine triad nucleotide-binding protein 1 Adenosine 5' monophosphoramidase, HINT 1, Histidine triad nucleotide binding protein 1, PKCI 1, PKCI1, Protein kinase C inhibitor 1, Protein kinase C interacting protein 1.