Recombinant Human OX40/TNFRSF4-Fc Chimera (carrier-free)
Description
OX40 (ACT35, CD134, TNFRSF4) is an approximately 48 kD transmembrane protein belonging to the TNF receptor superfamily. It is a 249 amino acid glycoprotein with a 41 amino acid cytoplasmic tail, 20 amino acid transmembrane domain, and a 185 amino acid extracellular domain. OX40 is a costimulatory molecule implicated in long-term T cell immunity. It is a receptor for TNFSF4, OX40L, GP34, and also acts as a receptor for human herpesvirus 6B/HHV-6B. OX40 is primarily expressed on activated T cells, including CD4 and CD8 T cells, Th1, Th2, and Th17 cells, and regulatory T cells. The main source of OX40L is antigen presenting cells. OX40L can also be induced on activated B cells, mature dendritic cells, Langerhans cells, and macrophages. OX40 and OX40L interactions regulate the division and survival of T cells. It inhibits the conversion of effector T cells into regulatory T cells (Tregs) and promote the recall response in memory T cells. OX40 and OX40L interactions are also involved in the development of multiple diseases including allergic airway inflammation, graft-versus-host disease and autoimmune disease.