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Description
ATG1(Ser556) Polyclonal Antibody. ? Target Background: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphoryla
Immunogen
KLH conjugated synthetic phosphopeptide derived from human ATG1 around the phosphorylation site of Ser556. Immunogen Range: 530-580/1050