Purity > 90% as determined by SDS-PAGE. MW: 12.3kDa. Partial: 678-751aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4