An inhibitor of JNK (IC50 = 280 nM); competitive for JNK1 binding with pepJIP1 (IC50 = 500 nM); selective for JNK over p38α, mTOR, and PI3Kα; inhibits c-Jun phosphorylation induced by TNF-α (EC50 = 12.4 μM); restores insulin sensitivity in a mouse model of type 2 diabetes when administered at 25 mg/kg 30 minutes prior to insulin; reduces human prostate strip contractions induced by phenylephrine or norepinephrine when applied at 30 μM and reduces phosphorylation of c-Jun, a JNK substrate,
Size
10 mg
Concentration
n/a
Applications
n/a
Other Names
c-Jun N-terminal Kinase Inhibitor X|JNK Inhibitor X