A group II mGluR agonist (Kis = 99 and 94 nM, respectively); inhibits forskolin-stimulated cAMP accumulation in cells expressing human mGluR2 and mGluR3 (EC50s = 5.1 and 24.3 nM, respectively); highly selective for mGluR2 and mGluR3 over mGluR4, mGluR7, mGluR1a, and mGluR5a (EC50s = >100 μM); suppresses electrically stimulated EPSPs in rat striatal neurons in vitro (EC50 = 20 nM); suppresses serotonin-induced EPSCs in rat medial prefrontal cortex in vitro (EC50 = 89.1 nM); attenuates the effects of PCP on working memory, stereotypy, locomotion, and cortical glutamate efflux in a rat model of schizophrenia (10 mg/kg); shows efficacy in animal models of anxiety, epilepsy, and withdrawal from nicotine and morphine