Purity ~90% (SDS-PAGE). PLCZ1, Recombinant, Human, aa1-415, His-SUMO-Tag (1-Phosphatidylinositol 4,5-bisphosphate Phosphodiesterase zeta-1). The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. Triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. Source: Recombinant protein corresponding to aa1-415 from human PLCZ1, fused to His-SUMO-Tag at N-terminal, expressed i