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| Antigenic Specificity | Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) |
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| Clone | 9H10 |
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| Host Species | Hamster |
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| Reactive Species | mouse |
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| Isotype | IgG |
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| Format | unconjugated |
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| Size | 0.5 mg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FACS),Immunoprecipitation (IP) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28. Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80/B7-1 and CD86/B7-2) on antigen-presenting cells. CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T-cell stimulation via the T cell receptor (TCR) complex. Whereas CD28 provides a positive costimulatory signal, CD152/CTLA-4 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signalling through the TCR through its association with tyrosine phosphatases such as SHP-2. |
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| Immunogen | Heat-killed Staphylococcus A bacteria coated with mouse CTLA-4/human IgG1 fusion protein 1 |
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| Other Names | CTLA-4|CTLA4|CD152|Cd152|Ctla-4|Ly-56|CD|CELIAC3|GRD4|GSE|IDDM12|sCTLA4 |
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| Gene, Accession # | Gene ID: 12477 |
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| Catalog # | ABIN135319 |
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| Price | |
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| Order / More Info | Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 8638161 |
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