Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
human
Isotype
n/a
Format
affinity purified
Size
100 μg
Concentration
n/a
Applications
Western Blotting (WB),Immunohistochemistry (IHC)
Reviews / Ratings
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Description
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008] Synonyms: CTLA4, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, ICOS, IDDM12