Purified (~70-90%). RON is a macrophage stimulating 1 receptor c-met-related tyrosine kinase. RON receptor tyrosine kinase interacts with HYAL2 receptor protein, rendering it functionally inactive. HYAL2 is a candidate tumor-suppressor glycosylphosphatidylinositol-anchored cell-surface protein that serves as an entry receptor for jaagsiekte sheep retrovirus, a virus that causes contagious lung cancer in sheep that is morphologically similar to human bronchioloalveolar carcinoma. It was shown that RON liberated from the association with HYAL2 becomes functionally active and activates the Akt and mitogen-activated protein kinase pathways. Source: Recombinant protein corresponding to human RON, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~71kD Specific Activity: 81nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL)