Immunohistochemistry (Paraffin): 1:50-100, Western Blot: 2-4 μg/mL
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Description
Osteopontin Polyclonal Antibody. Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D.
Immunogen
n/a
Other Names
SPP-1, SPP1/CALPHA1 fusion, bone sialoprotein 1, bone sialoprotein I, early T-lymphocyte activation 1, nephropontin, osteopontin, osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1), secreted phosphoprotein-1 (osteopontin, bone sialoprotein), urinary stone protein, uropontin