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Description
Neuroketals and neuroprostanes are a class of compounds that result from the oxidation of docosahexenoic acid (DHA), which is enriched in the brain and retina, especially the synaptic membranes and retina. DHA is a membrane polyunsaturated fatty acid that is especially vulnerable to free radical attack because hydrogen radicals easily remove its double bonds. The DHA is oxidized to isoprostane-like compounds called neuroprostanes, which can dehydrate to form highly reactive A4/J4 neuroprostanes . Neuroprostanes can also undergo rearrangement to form D- and E-ring neuroprostanes. These reactive neuroprostanes are called neuroketals because DHA is so concentrated in the nervous system.
Immunogen
Neuroketal antibody was raised in goat using neuroketal-Conjugate as the immunogen.