Growth and differentiation factor-associated serum protein-1 (GASP-1) is a secreted inhibitory TGF-β binding protein that contains multiple protease inhibitor structural domains. It is expressed primarily in the ovary, testis, and brain, and can act as a potent soluble inhibitor of myostatin and GDF-11, but not Activin-A. The GASP-1 gene encodes a 571 amino acid protein that contains a 29 amino acid secretion signal sequence, and multiple identifiable structural features, including a WAP domain, a follistatin/Kazal domain, an immunoglobulin domain, two tandem Kunitz domains, and a netrin domain. Recombinant human GASP-1 is a 542 amino acid protein that migrates at an apparent molecular weight of approximately 55-66 kDa by SDS-PAGE analysis under non-reducing conditions.
Size
Various Sizes
Concentration
n/a
Applications
Cell Culture
Other Names
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2;Growth and differentiation factor-associated serum protein 1;GASP-1;hGASP-1;WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein;WFIKKN-related protein;WFIKKN2;GASP1, WFIKKNRP;UNQ9235/PRO31996; GDF-associated serum protein-1, GASP, KIAA0443, WFIKKNRP