Immunohistochemistry (Frozen): 5-15 μg/mL, Western Blot: 0.1 μg/mL
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Description
DMP1 Polyclonal Antibody. Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix
Immunogen
n/a
Other Names
DMP1, dentin matrix acidic phosphoprotein, dentin matrix protein 1