ATG3 Autophagy Related 3 Homolog (S. Cerevisiae) (ATG3) protein (His tag)
Description
Autophagy-related 3 (ATG3), also known as Apg3L and Apg3p, functions as a regulatory component of autophagosome biogenesis necessary for autophagy. It is a 314 amino acid (aa) protein with a predicted molecular weight of 36 kDa. ATG3 exhibits 98% aa sequence identity with both its mouse and rat orthologs. It is a ubiquitin-conjugating (E2)-like enzyme that works in concert with Atg12-Atg5, a ubiquitin Ligase (E3)-like enzyme conjugate, to catalyze the transfer of Atg8 (LC3, GATE-16, and GABARAP in mammals) to phosphatidylethanolamine (PE) in the developing autophagosome membrane. This lipidation of Atg8 proteins is necessary for autophagosome maturation.