Recombinant Human Dual specificity protein phosphatase 26
Description
1-211aa; Full Length. MW: 39.93kD. Purity >90% as determined by SDS-PAGE. Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).
MKP-8, a novel MAPK phosphatase that inhibits p38 kinase.Vasudevan S.A., Skoko J., Wang K., Burlingame S.M., Patel P.N., Lazo J.S., Nuchtern J.G., Yang J.Biochem. Biophys. Res. Commun. 330:511-518(2005) A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity.Yu W., Imoto I., Inoue J., Onda M., Emi M., Inazawa J.Oncogene 26:1178-1187(2007) Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in