Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) (aa 1-17), (N-Term)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
human, rat
Isotype
n/a
Format
immunogen affinity purified
Size
100 μg
Concentration
n/a
Applications
Western Blotting (WB),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Reviews / Ratings
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Description
The human CDC25 tyrosine phosphatases trigger activation of CDC2 by removing inhibitory phosphate from tyrosine and threonine residues of the cyclin-dependent kinases. The genes encoding these phosphatases are suspected of being potential oncogenes because of their role in promoting cell division. Three human CDC25 genes have been identified: CDC25A, CDC25B, and CDC25C. The CDC25A gene is mapped to 3p21. In rodent cells, human CDC25A or CDC25B but not CDC25C phosphatases cooperate with either the gly12-to-val mutation of the HRAS gene or loss of RB1 in oncogenic focus formation.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Cdc25A(1-17aa MELGPEPPHRRRLLFAC), identical to the related rat and mouse sequences.