Death-Domain Associated Protein (DAXX) (aa 558-740), (C-Term)
Clone
DAXX-01
Host Species
Mouse
Reactive Species
human
Isotype
IgG1
Format
Protein A purified
Size
0.1 mg
Concentration
n/a
Applications
Immunocytochemistry (ICC),Western Blotting (WB)
Reviews / Ratings
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Description
Daxx is an apoptosis-modulating death domain-associated protein with functions in transcriptional regulation. Daxx functions bot in cytoplasm, where it interacts with Fas, and in nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependent regulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells to apoptosis, but on the other hand, this protein may also serve in preventing apoptosis in the early embryo. Even regarding the transcription, Daxx can serve both as a corepressor and a coactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1).
Immunogen
Recombinant C-terminal part (aa 558-740) of human Daxx.