Purity: > 90% by SDS - PAGE Format: Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.. FRZB, also known as secreted frizzled-related protein 3, is a member of the family of Wnt-binding proteins with homology to the ligand binding domain of the Frizzled receptors. It is widely expressed in adult mammalian tissues and in chondrocytes. It is a key factors in blocking hypertrophic differentiation of human MSCs (hMSCs) and important in skeletal development in the embryo and fetus. It acts as an agonist of Wnt signaling and promotes invasive behavior. It has a role in regulating cell growth and differentiation in specific cell types. It also functions as a tumor suppressor in a variety of cancers. Recombinant human FRZB, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.