Recombinant Human Transcription factor SOX-2 (SOX2)
Description
Purity > 90% as determined by SDS-PAGE. MW: 50.3kDa. Full Length: 1-317aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in bryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early bryogenesis and for bryonic st cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural st cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation.