Recombinant Human Transcription factor SOX-2 (SOX2)
Description
Purity > 90% as determined by SDS-PAGE. MW: 50.3kDa. Full Length: 1-317aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).