Recombinant Human Transcription intermediary factor 1-alpha (TRIM24), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 30.5kDa. Partial: 891-1012aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
E3 ubiquitin-protein ligase TRIM24RING finger protein 82Tripartite motif-containing protein 24