Recombinant Human Transforming growth factor beta activator LRRC33 (NRROS), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 73.5kDa. Extracellular Domain: 19-650aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Homo sapiens (Human). Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex. May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production.