An inhibitor of PGC-1α, increases acetylation of PGC-1α; decreases mRNA expression of Pck1 and G6Pc in primary hepatocytes following glucagon stimulation; reduces fasting blood glucose and Pck1 expression in the liver in a dietary model of type II diabetes in mice at a dose of 45 mg/kg, i.p, for four days; enhances glucose tolerance and insulin sensitivity in two mouse models of obesity