A natural kavalactone that enhances the binding of bicuculline at the GABA receptor GABAA at 1.0 μM; binds the CB1 receptor with a Ki value of 0.72 μM; blocks the activation of NF-κB by TNF-α; inhibits anchorage-dependent and independent growth of bladder cancer cell lines through induction of autophagic cell death (IC50s = 15-59 mg/mL)
Size
5 mg
Concentration
n/a
Applications
n/a
Other Names
39986-88-4 18693-06-6 89272-44-6 NF-kB inflammation CBs kavalactone kava plants P. methysticum bicuculline GABA receptors GABAA agonist antagonist NF-κB NF-kappaB NF-.kappa.B central CB1