Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA) (AA 1-313) protein (His tag)
Description
SGTA is a ubiquitously expressed protein that contains three TPR protein-protein interaction duplicates. SGTA takes part as a component of the androgen receptor (AR)-chaperone-cochaperone complex, functions as a cochaperone and participates in androgen signaling. SGTA acts as a cochaperone that binds directly to HSC70 and HSP70 and mediatess their ATPase activity. While being involved in apoptosis and androgen signaling, SGTA is a possible molecule for polycystic ovary syndrome, a disorder characterized by androgen excess, obesity and menstrual disturbances. Synonyms: alphaSGT, hSGT, SGT, Vpu-binding protein, UBP, Small glutamine-rich tetratricopeptide repeat-containing protein alpha, Alpha-SGT, SGT1