Immunohistochemistry (Paraffin): 5 μg/mL, Western Blot: 3-5 μg/mL
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Description
DLL3 Polyclonal Antibody. Delta-like protein 3 is a ligand for the Notch signaling pathway. It inhibits primary neurogenesis. DLL3 plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Defects in DLL3 are the cause of Spondylocostal dysostosis autosomal recessive type 1 (SCDO1). Mutations in DLL3 gene cause truncal shortening relative to their limbs, which leads to abdominal protrusion, abnormal spinal curvature and sometimes a plagiocephaly-torticollis sequence. It may be required to divert neurons along a specific differentiation pathway.
Immunogen
n/a
Other Names
SCDO1, delta-like protein 3, delta3, drosophila Delta homolog 3