RLN2, Recombinant, Human (Prorelaxin H2, bA12D24.1.1, bA12D24.1.2, H2, RLXH2, Relaxin-2)
Description
Purity ~98% (SDS-PAGE and HPLC). Relaxin-2 is a peptide hormone structurally related to insulin, which is expressed in the placenta, decidua, prostate, and in the ovary during pregnancy. Of the three known relaxin genes, Relaxin-2 is the only relaxin known to circulate in the blood. Relaxin-2 binds specifically to the LGR7 and LGR8 receptors, previously identified as an ``orphan'' G protein coupled receptors. Signaling by Relaxin-2 through its target receptors enhances the growth of pubic ligaments and ripening of the cervix during birth. Recombinant Relaxin-2 is a nonglycosylated 6kD disulfide linked heterodimeric protein consisting of a 24aa A-chain and a 29aa B-chain. Source: Recombinant protein corresponding to human Relaxin-2, expressed in E.coli. Endotoxin: <0.1ng/ug (1EU/ug) AA Sequence: A-Chain: QLYSALANKC CHVGCTKRSL ARF B-Chain: DSWMEEVIKL CGRELVRAQI AICGMSTWS