Recombinant Human Hypoxia-inducible factor 1-alpha (HIF1A), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 31kDa. Partial: 579-826aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in bryonic vascularization, tumor angiogenesis and pathophysiology of ischic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response elent (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX ses to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1Class E basic helix-loop-helix protein 78; bHLHe78Member of PAS protein 1; PAS domain-containing protein 8