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Description
AKR1C4 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. This AKR1C4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-39 amino acids from the N-terminal region of human AKR1C4.
Immunogen
Human AKR1C4.
Other Names
3-alpha-HSD1; 3-alpha-hydroxysteroid dehydrogenase type I; Chlordecone reductase; CDR; Dihydrodiol dehydrogenase 4; DD-4; DD4; HAKRA; AKR1C4; CHDR; 3-alpha-HSD; C11; aldo-keto reductase family 1, member C4; HGNC:387; MGC22581; 3-alpha hydroxysteroid dehydrogenase, type I; 3 alpha-hydroxysteroid dehydrogenase/dihydrodiol dehydrogenase 4; 3-alpha-hydroxysteroid dehydroge; Aldo-keto reductase family 1 member C4; aldo-keto reductase family 1 member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase; type I; dihydrodiol dehydrogenase 4)