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Description
Recognizes the human CD53 cell surface antigen, a glycoprotein of 32-40 kDa. CD53 is expressed by all leucocytes, but is absent from erythrocytes and platelets. A number of eukaryotic cell surface antigens have been shown to be related, including mammalian leukocyte antigen CD37, mammalian lysosomal membrane protein CD63, human tumour-associated antigen CD-029, and several others. These proteins are all type II membrane proteins: they contain an N-terminal transmembrane (TM) domain, which acts both as a signal sequence and a membrane anchor, and 3 additional TM regions (hence the name `TM4'). The sequences contain a number of conserved cysteine residues. The antigen, 32-40kDa, is a single chain glycoprotein on most leucocytes. There is no cross- reactivity with erythrocytes or platelets. The antibody recognises a broad span of leucocytes of both normal and neoplastic plasma cells.
Immunogen
Leucocytes of patient suffering from a LGL-type leukaemia.