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Description
Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. DAAM1 contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by DAAM1, which is thought to function as a scaffolding protein. This DAAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1034-1063 amino acids from the C-terminal region of human DAAM1.
Immunogen
Human DAAM1.
Other Names
DAAM1; KIAA0666; Disheveled-associated activator of morphogenesis 1; Dishevelled Associated Activator Of Morphogenesis 1