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Description
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Purified His-tagged SUMO2 protein was used to produced this monoclonal antibody.
Immunogen
Human SUMO2.
Other Names
HSMT3; SMT3B; SMT3H2; SUMO-3; Sentrin-2; Ubiquitin-like protein SMT3B; SUMO3; Smt3A; Small ubiquitin-related modifier 2CuratedSUMO-2Curated; HSMT31; SUMO2; SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); MGC117191; SMT3 homolog 2; Ubiquitin-like protein SMT3A; Small ubiquitin-related modifier 2