64-399. Partial. MW: 64.2kD. Purity >90% as determined by SDS-PAGE. Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.
Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment.Pastorek J., Pastorekova S., Callebaut I., Mornon J.-P., Zelnik V., Opavsky R., Zat'Ovicova M., Liao S., Portetelle D., Stanbridge E.J., Zavada J., Burny A., Kettmann R.Oncogene 9:2877-2888(1994) Molecular cloning and immunogenicity of renal cell carcinoma-associated antigen G250.Grabmaier K., Vissers J.L.M., De Weijert M.C.A., Oo