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Description
Purified anti-ERK1. ERK1 is a member of mitogen-activated kinases (MAPKs) of serine/threonine protein kinases. ERK1 and ERK2 share 85% homology and both are involved in the MAP kinase signaling cascade. ERK1/2 can be activated by a range of extracellular stimuli, such as mitogen, growth factors, neurotransmitters, chemokines, and cytokines, through receptor tyrosine kinases (RTK), G protein-coupled receptors (GPCRs), or protein kinase C (PKC). Upon stimulation, ERK1/2 are phosphorylated by the upstream kinase MEK on residues Thr202 and Tyr204 and in turn phosphorylate many other downstream molecules that are involved in a range of cellular processes such as cell proliferation, differentiation, motility and cell death.
Immunogen
Partial human ERK1 recombinant protein (180-379 a.a.) expressed in E. coli.