Western Blot (WB), Immunofluorescence Microscopy (IF)
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Description
Purified anti-FAK. FAK (Focal adhesion kinase) is an intracellular, highly conserved, nonreceptor tyrosine kinase encoded by?PTK2 located on human chromosome 8q24.3. It is ubiquitously expressed in all cells and was initially identified in v-Src transformed chicken embryo fibroblasts. FAK is a multi-functional regulator of cell signaling within the tumor microenvironment. During development and in various tumors, FAK promotes cell motility, survival and proliferation through kinase-dependent and -independent mechanisms. FAK is associated with many aspects of metastasis such as adhesion, migration and invasion. FAK is overexpressed and activated in a variety of cancers including ovary, colon, breast, lung, thyroid, head and neck, liver, pancreatic and esophageal and is correlated with poor survival rates. Small molecule FAK inhibitors are emerging as promising chemotherapeutics, as FAK inhibition in mouse models prevents tumor growth, metastasis, vascular permeability, and angiogenesis.
Immunogen
Partial human FAK (701-950 a.a.) expressed in E. coli.