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| Antigenic Specificity | Bcl-2 |
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| Clone | 100 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | Alexa Fluor? 488 conjugate |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | Intracellular Staining for Flow Cytometry (ICFC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Alexa Fluor? 488 anti-Bcl-2. Bcl-2 is a conserved anti-apoptotic protein that plays important roles in normal immunity. It forms homodimers or heterodimers with other Bcl-2 family members. This protein regulates apoptosis through controlling mitochondrial fusion and fission. Phosphorylation of Bcl-2 has been shown to enhance activity to allow response to extracellular growth-factor-mediated signals. Bcl-2 is also regulated by IRES, miR-15a, miR-16-1 and RNA-BP nucleolin. Chromosome 18q21.3 translocation and overexpression of Bcl-2 is frequently observed in follicular lymphomas and some diffuse large B-cell lymphomas. |
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| Immunogen | Synthetic peptide of amino acids 41-54 of human bcl-2 oncoprotein |
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| Other Names | B-Cell CLL/Lymphoma 2,Protein Phosphatase 1, Regulatory Subunit 50 |
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| Gene, Accession # | Gene ID: 596 |
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| Catalog # | 658704 |
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| Price | |
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| Order / More Info | Bcl-2 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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