A selective PDK1 inhibitor (IC50 = ~10 nM) that even at 100-fold higher concentrations does not affect the activity of 93 other protein kinases, including that of 13 closely related AGC kinase family members; suppresses T-loop phosphorylation and activation of SGK, S6K1, and RSK, as well as the activation of Akt
Size
25 mg
Concentration
n/a
Applications
n/a
Other Names
3-phosphoinositide-dependent protein kinase 1 PDK1 signal transduction inhibitor GSK 2334470 biochemical cancer inhibit intracellular signaling PDK-1