A potent and selective inhibitor of Wip1 (IC50 = 6 nM); increases phosphorylation of Wip1 substrates and blocks cell cycling in cancer cells; orally bioavailable, causing inhibition of lymphoma xenograft growth in mice
Size
10 mg
Concentration
n/a
Applications
n/a
Other Names
biochemical inhibitor inhibit phosphatase cancer signal transduction cell cycle intracellular signaling Wip1 protein phosphorylation hematopoietic Wip1-amplified wild-type P53 lymphoma magnesium-dependent 1 δ PPM1D PP2Cδ GSK 2830371