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Description
Purified anti-FGF-3. FGF-3 is a member of the fibroblast growth factor family. The amplification of the FGF-3 gene has been found in many cancer types including squamous cell carcinoma, epithelial ovarian tumors, breast cancer and bladder cancer. FGF-3 is also associated with tumor metastasis and recurrence in human hepatocellular carcinoma. Like many other FGF proteins, FGF-3 plays an important role in embryonic development. FGF-3 is needed for normal inner ear development including placode induction, maintenance, and otic vesicle formation. The role of FGF-3 in ear development is conserved amongst different vertebrates including mouse, chicken, and zebrafish. In addition to FGF-3, it has been shown that FGF-8 and FGF-10 play redundant and unique roles in ear development as well. FGF-3 is also important for early hindbrain patterning. FGF-3 is derived from hindbrain boundary cells and regulates the expression of multiple markers at hindbrain boundaries. It has been reported that FGF-3 is involved in cardiovascular development in two forms. These two forms of FGF-3 are a secreted form that induces proliferation and another form that localizes in the nucleus and inhibits cell proliferation. The nuclear isoform binds rpS2 and this binding has been suggested to interfere with ribosomal biogenesis.
Immunogen
Human FGF-3 recombinant protein (28-212 a.a.) expressed in E.coli.